of the whole article in a thesis or dissertation. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. The important biomedical applications of zinc oxide nanoparticles are listed as below:- 1. On the basis of thermodynamics, zinc oxide (ZnO) nanoparticles (NPs) should dissolve faster and to a greater extent than bulk ZnO particles (equivalent spherical diameter >100 nm). In addition, ZnO NPs-treated SKOV3 cells resulted in an upregulation of LC3-I/II and p53 expression, which further induced autophagic cell death. Hussein et al. There are safety concerns related to ZnO NPs are listed as a kind of safe substance by the FDA. Arakha et al. Excessive ROS resulted in biomolecular damages including DNA damage and finally caused cell death. Moreover, with the ability to decrease blood glucose and increase in insulin levels, ZnO NPs have shown the promising potential in treating diabetes and attenuating its complications, which can be further evaluated. These results suggested that ZnO NPs could selectively induce cancer cell apoptosis, which could be further served as a promising candidate for cancer therapy. Instructions for using Copyright Clearance Center page for details. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [. with the reproduced material. Authors contributing to RSC publications (journal articles, books or book chapters) They also detected the antibacterial activity of the ZnO NPs in cholera toxin (CT) mouse models. These results would damage bacterial membrane, increase permeabilization, and substantially modify their morphology [85]. ZnO NPs have been widely used in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell proliferation. Diabetes mellitus is a serious public health problem, and the WHO has estimated that, in 2014, there were more than 400 million adults with diabetes all over the world [99]. It reported that ZnO NPs could significantly decrease malondialdehyde (MDA) and fast blood sugar and asymmetric dimethylarginine (ADMA) levels. A. Kattaia, and S. A. Kandeel, “Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes,”, S. C. Asani, R. D. Umrani, and K. M. Paknikar, “In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles,”, K. Shanker, J. Naradala, G. K. Mohan, G. S. Kumar, and P. L. Pravallika, “A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and, R. M. El-Gharbawy, A. M. Emara, and S. E. Abu-Risha, “Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in type-2 diabetes,”, L. Ferrero-Miliani, O. H. Nielsen, P. S. Andersen, and S. E. Girardin, “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation,”, M. Boguniewicz and D. Y. Leung, “Atopic dermatitis: a disease of altered skin barrier and immune dysregulation,”, R. Jurakic Toncic and B. Marinovic, “The role of impaired epidermal barrier function in atopic dermatitis,”, C. Wiegand, U. C. Hipler, S. Boldt, J. Strehle, and U. Wollina, “Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis,”, M. Ilves, J. Palomaki, M. Vippola et al., “Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model,”. However, excessive ROS will lead to mitochondrial damage and result in the loss of protein activity balance that finally causes cell apoptosis [60]. Zinc oxide nanoparticles were provided by Institute of Feed Science, Zhejiang University, Zhejiang, China. In addition, it can be coated on various substrates to prevent bacteria from adhering, spreading, and breeding in medical devices. Because of FA-mediated endocytosis and intracellular release within the acidic endolysosome, the FCP-ZnO nanocomplexes not only exhibited significantly higher cytotoxicity in vitro MDA-MB-231 cells but also reduced MDA-MB-231 xenograft tumours in nude mice. 2013). The hyperglycemia can directly enhance an inflammatory state by regulating C-reactive protein (CRP) and cytokines, such as interleukins, which is involved in the development of cardiovascular diseases. This perspective outlines the current state of knowledge concerning the interaction of zinc oxide nanoparticles with eukaryotic cells and the human body. The ZnO NPs-induced apoptosis was mainly through both extrinsic and intrinsic apoptotic pathways, and some antiapoptotic genes of Bcl-2, AKT1, and JERK/2 were downregulated, while proapoptotic genes of p21, p53, JNK, and Bax were upregulated. (2008). Reddy prepared ZnO NPs with sizes of ∼13 nm and examined their antibacterial (E. coli and S. aureus) activities [78]. Jiang et al. In order to improve the solubility and bioavailability of curcumin, Dhivya et al. A. Othman, C. Greenwood, A. F. Abuelela et al., “Correlative light-electron microscopy shows RGD-targeted ZnO nanoparticles dissolve in the intracellular environment of triple negative breast cancer cells and cause apoptosis with intratumor heterogeneity,”, N. Puvvada, S. Rajput, B. N. Kumar et al., “Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression,”, N. Tripathy, R. Ahmad, H. A. Ko, G. Khang, and Y. produced hyaluronan/ZnO nanocomposite (HA/ZnO) through green synthesis for the first time for cancer treatment [57]. Zinc oxide is characterized by a good biocompatibility which allows the exploitation of its antibacterial, antifungal, antiviral, and anti-cancer qualities in a therapeutic setting. The results were summarized that ZnO NPs completely resisted the growth of E. coli at concentrations of about 3.4 mM but inhibited growth of S. aureus at much lower concentrations (≥1 mM). The solubility of Zn in Zn fertilizers plays an important role in the agronomic effectiveness of the fertilizer. The main mechanism by which PEG-ZnO kills a cancer cell is by generating ROS and triggering p53-dependent apoptosis leading to cell death. As far as method of formation is concerned, ZnO NPs can be synthesized by several chemical methods such as precipitation method, vapor transport method, and hydrothermal process. It exhibited emission colors of blue, green, yellow, and orange [123]. De Angelis, F. Barone, A. Zijno et al., “Comparative study of ZnO and TiO, Y. Cao, M. Roursgaard, A. Kermanizadeh, S. Loft, and P. Moller, “Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to Caco-2 cells,”, X. Fang, L. Jiang, Y. Gong, J. Li, L. Liu, and Y. Cao, “The presence of oleate stabilized ZnO nanoparticles (NPs) and reduced the toxicity of aged NPs to Caco-2 and HepG2 cells,”, J. Bai Aswathanarayan and R. Rai Vittal, “Muddegowda U: anticancer activity of metal nanoparticles and their peptide conjugates against human colon adenorectal carcinoma cells,”, V. Sharma, D. Anderson, and A. Dhawan, “Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2),”, M. J. Akhtar, M. Ahamed, S. Kumar, M. M. Khan, J. Ahmad, and S. A. Alrokayan, “Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species,”, Y. Deng and H. Zhang, “The synergistic effect and mechanism of doxorubicin-ZnO nanocomplexes as a multimodal agent integrating diverse anticancer therapeutics,”, A. Aiming at the development of nanomedicine against cholera, Sarwar et al. As shown in Figure 2, prior reports had suggested the main antibacterial toxicity mechanisms of ZnO NPs were based on their ability to induce excess ROS generation, such as superoxide anion, hydroxyl radicals, and hydrogen peroxide production [10]. Exposure of human broncho-alveolar carcinoma A549 cells to zinc oxide nanoparticles (ZnO-NPs) exhibits steeper dose-dependent cytotoxicity than is seen with other metal oxides (Lin et al., 2009). They exhibit antibacterial, anti-corrosive, antifungal and UV filtering properties. Ilves et al. Interaction ZnO NPs with HT1080 cell has relatively higher ROS generation. Aims: To investigate antibacterial activities of zinc oxide nanoparticles (ZnO NP) and their mode of action against an important foodborne pathogen, Escherichia coli O157:H7. Typical researches about biological imaging of ZnO NPs. Puvvada et al. They treated drug sensitive leukemia line K562 cells with ZnO nanosheets, and the yellow-orange light emission was clearly observed around or inside the cells under UV irradiation (365 nm) at room temperature [122]. SEM images of the ZnO nanoparticles synthesized using Cassava … ZnO NPs, as a new type of the low-cost and low-toxicity nanomaterial, have attracted tremendous interest in various biomedical fields, including anticancer, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities, as well as for drug delivery and bioimaging applications [9, 12]. The importance of zinc as a trace metal in the human body has long been overlooked. This article provides further detail on the properties and applications of zinc oxide nanoparticles (ZnO). Some possible ways to produce ZnO nano-particles are laser ablation, hydrothermal methods, electrochemical depositions, sol–gel method, chemical vapor deposition, thermal decomposition, Wiegand explored the role of ZnO-functionalized textile fibers in the control of oxidative stress in AD in vitro and in vivo [114]. Corresponding authors, a ZnO NPs have exhibited promising biomedical applications based on its anticancer, antibacterial, antidiabetic, anti-inflammatory, drug delivery, as well as bioimaging activity. Scr Mater. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. 2014; 10(6): 1195-208. The mechanism of ZnO NPs-induced toxicity in human liver cells [. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. Recently, various approaches including physical, chemical and biological (“green chemistry”) have been used to prepare ZnO nanocomposites with different morphologies. Effect of particle size on the UV absorbance of zinc oxide nanoparticles. Moghaddam et al. Nowadays, the development of green chemistry has attracted more and more attention because it is mostly environmentally friendly [23]. Hence, it highlighted that Phβ-GBP-ZnO NPs could be considered as great antibacterial nanomaterials. Hariharan et al. Zinc Oxide nanoparticles have been synthesized by two simple routes using Aloe vera (green synthesis, route I) or Cassava starch (gelatinization, route II). Photo-triggered ROS generation by ZnO NPs and the resulting phototoxicity in cells have found use in antibacterial and anticancer applications. Schematic illustration of antibacterial activity of ZnO NPs. The exact physical and chemical properties of zinc oxide nanoparticles depend on the different ways they are synthesized. described a straightforward, inexpensive, and ecofriendly ZnO NPs using the root extract of P. tenuifolia and the anti-inflammatory activities were investigated in LPS-stimulated RAW 264.7 macrophages [30]. It was worth to note that these nanoparticles did not show any remarkable toxicity for human hepatoma cells when their concentrations were less than 0.2 mg/mL. ZnO nanopowders are available as powders and dispersions. This perspective outlines the current state of knowledge concerning the interaction of zinc oxide nanoparticles with eukaryotic cells and the human body. Abstract:Zinc oxide (ZnO) is a metal oxide well known for its photocatalytic property and widely used in cosmetics. It also participates in insulin synthesis, storage, and secretion [102]. Zhang et al. However, most studies have focused on their inhibitory actions on bacterial infections, and there is limited studies evaluating the interaction between ZnO-NPs and viruses. Zinc is a Block D, Period 4 element, while Oxygen is a Block P, Period 2 element. Nanomedicine. For example, Chakraborti et al. Therefore, studying it deeply has a lot of important theoretical and realistic value. Furthermore, the luminescence was very stable during cell culturing and the cells were alive at 45 min of exposure. The inflammatory markers, interleukin-1 (IL-1α) and CRP, were also notably decreased after ZnO NPs treatment, concomitant with an increase in nitric oxide (NO) and serum antioxidant enzyme (PON-1) levels in diabetic rats. The XRD patterns and Raman spectra show that both synthesis routes lead to single-phase ZnO. Among our customers we find personal care products&cosmetics, electronics, coating and tiles industry. Hence, autophagy not only promotes cell survival but also activates lethal mechanisms in cancer cells, thus be considered as an important event in nanoparticle-induced cytotoxicity. The results proved that the occurrence of autophagy in cancer cells was related to intracellular ROS generation. Therefore, in subsequent research work, we should attach more importance to their molecular mechanism in vitro and vivo and overcome its limitations in cancer therapy. But up to now, the advanced anticancer mechanism study of ZnO NPs is still lacked of, especially in cellular and molecular mechanism strengthening. After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. By targeting the specific sites of cancer cells, nanoparticle-based drug delivery could reduce the overall amount of drugs used and thus minimize undesirable side effects [9, 66]. Textiles have the longest and most intense contact with the human skin. elucidated the efficiency of ZnO nanoparticles (NPs) against different cancer cell lines. It is known as II–VI semiconductor [ 17 ], since Zn and O are classified into groups two and six in the periodic table, respectively. However, they have also been found to adversely affect organisms; previously we found that ZnO NPs disrupt pubertal ovarian development, inhibit embryonic development by upsetting γ-H2AX and NF-κB … Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication B. Moghaddam, M. Moniri, S. Azizi et al., “Eco-friendly formulated zinc oxide nanoparticles: induction of cell cycle arrest and apoptosis in the MCF-7 cancer cell line,”, J. Liu, X. Ma, S. Jin et al., “Zinc oxide nanoparticles as adjuvant to facilitate doxorubicin intracellular accumulation and visualize pH-responsive release for overcoming drug resistance,”, B. The increasing focus on nano zinc oxide resulted in the invention and development of methods of nanoparticles synthesis. Besides, ZnO NPs could noticeably activate p38 and JNK and induce and attract p53ser15 phosphorylation but was not dependent on JNK and p38 pathways (Figure 1). Autophagy is a highly regulated catabolic process that activated in response to different kinds of stresses like damaged organelles, ROS, anticancer agents, and protein aggregation. fabricated ZnO NPs using the chemical precipitation method and further evaluated their anticancer activity [64], which found that ZnO NPs with different sizes could obviously inhibit the proliferation of fibrosarcoma HT1080 cells. A. Sheikh, K. M. Hoque, and P. Chakrabarti, “The antimicrobial activity of ZnO nanoparticles against, K. Ghule, A. V. Ghule, B. J. Chen, and Y. C. Ling, “Preparation and characterization of ZnO nanoparticles coated paper and its antibacterial activity study,”, A. Iswarya, B. Vaseeharan, M. Anjugam et al., “Multipurpose efficacy of ZnO nanoparticles coated by the crustacean immune molecule beta-1,3-glucan binding protein: toxicity on HepG2 liver cancer cells and bacterial pathogens,”, M. Shaban, F. Mohamed, and S. Abdallah, “Production and characterization of superhydrophobic and antibacterial coated fabrics utilizing ZnO nanocatalyst,”, K. Karthik, S. Dhanuskodi, C. Gobinath, and S. Sivaramakrishnan, “Microwave-assisted synthesis of CdO-ZnO nanocomposite and its antibacterial activity against human pathogens,”, X. Bellanger, P. Billard, R. Schneider, L. Balan, and C. Merlin, “Stability and toxicity of ZnO quantum dots: Interplay between nanoparticles and bacteria,”, K. Dedkova, B. Janikova, K. Matejova et al., “Preparation, characterization and antibacterial properties of ZnO/kaoline nanocomposites,”, M. Ramani, S. Ponnusamy, C. Muthamizhchelvan, J. Cullen, S. Krishnamurthy, and E. Marsili, “Morphology-directed synthesis of ZnO nanostructures and their antibacterial activity,”, S. Soren, S. Kumar, S. Mishra, P. K. Jena, S. K. Verma, and P. Parhi, “Evaluation of antibacterial and antioxidant potential of the zinc oxide nanoparticles synthesized by aqueous and polyol method,”, W. Salem, D. R. Leitner, F. G. Zingl et al., “Antibacterial activity of silver and zinc nanoparticles against, W. Wu, T. Liu, H. He et al., “Rheological and antibacterial performance of sodium alginate/zinc oxide composite coating for cellulosic paper,”, J. Lee, K. H. Choi, J. Min, H. J. Kim, J. P. Jee, and B. J. ZnO NPs prepared by this method exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity. Zinc oxide nanoparticles (ZnO-NPs) are widely used in almost every area of life. Mechanistic studies had proved that the loss of mitochondrial membrane potential-mediated HepG2 cell apoptosis was mainly due to the decrease in mitochondrial membrane potential and Bcl-2/Bax ratios as well as accompanying with the activation of caspase-9. it in a third party non-RSC publication you must This work was financially supported by the Macau Science and Technology Development Fund (no. We believe that nanomaterials would dramatically promote the development of medicine, and ZnO nanoparticles are expected to make more exciting contributions in these fields. In all cases the Ref. You do not have JavaScript enabled. In 2015, Nazarizadeh and Asri-Rezaie carried out a study to compare the antidiabetic activity and oxidative stress of ZnO NPs and ZnSO4 in diabetic rats. Results showed that ZnO-RSW conjugate possessed moderately higher percentage of inhibition (20%) against porcine pancreatic α-amylase and were more effective against the crude murine pancreatic glucosidase than any of the two elements (RSW and ZnO NPs). The Phβ-GBP-ZnO NPs were spherical in shape with a particle size of 20–50 nm and restrained the growth of S. aureus and P. vulgaris. Different types of drugs such as doxorubicin, paclitaxel, curcumin, and baicalin or DNA fragments could be loaded onto the ZnO NPs to show better solubility, higher toxicity compared with individual agents, and effective delivery into cancer cells [48, 67–69]. Lately, it has gained more importance in its biomedical applications, especially in cancer therapy. It easily diffuses into the food material, kill the microbes, and prevent human being from falling ill. Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants [111]. The theory analysis and experimental research proved that ZnO NPs with less side effect present greater selectivity among normal and cancerous cells. Pardeshi and Patil synthesized ZnO NPs with different morphologies and crystallite sizes using this method by varying the calcination temperature from 400°C to 900°C. Presently, Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) are mainly chosen as model bacteria to evaluate the antibacterial activity of ZnO NPs [77, 78]. The obtained ZnO@silica core-shell nanoparticles exhibited excellent water stability, and the visible emissions of ZnO were retained. is available on our Permission Requests page. Sharma et al. For AFM, the zinc oxide nanoparticles suspended into water were placed onto cleaved mica … synthesized PEG-modified ZnO NPs and tested it against different breast cancer cell lines [74]. explored the effects of ZnO NPs on human liver cancer HepG2 cells and its possible pharmacological mechanism [42]. Explore the latest full-text research PDFs, articles, conference papers, preprints and more on ZINC OXIDE NANOPARTICLES. Go to our Although ZnO in nanoparticle form is a promising antibacterial agent due to its wide activity against both Gram-positive and Gram-negative bacteria, the exact antibacterial mechanism of ZnO NPs has not been well established. ZnO NPs present certain cytotoxicity in cancer cells mainly by themselves based on a higher intracellular release of dissolved zinc ions, followed by increased ROS induction and induced cancer cell death via the apoptosis signaling pathway. investigated the regulatory mechanism of autophagy and the link between autophagy and ROS in ZnO NPs-treated lung epithelial cells [65]. Department of Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany. The conjugated ZnO-RSW displayed 61.93% of inhibition in glucosidase while the bare ZnO NPs and RSW showed 21.48% and 5.90%, respectively. Due to inherent toxicity of ZnO NPs, they possess strong inhibition effects against cancerous cell and bacteria, by inducing intracellular ROS generation and activating apoptotic signaling pathway, which makes ZnO NPs a potential candidate as anticancer and antibacterial agents. Previous studies have indicated that ROS and autophagy are involved in the cytotoxicity of ZnO NPs, but the regulatory mechanisms between autophagy and ROS remain to be elucidated. Furthermore, coupled with ultraviolet (UV) illumination, Dox-ZnO nanocomplexes caused more cell death through photocatalytic properties and synergistically triggered caspase-dependent apoptosis. Encouraging, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the normal human lung fibroblast (MRC-5) cell line. vera) and their antibacterial activity against pathogens,”, K. Ali, S. Dwivedi, A. Azam et al., “Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates,”, R. Yuvakkumar, J. Suresh, A. J. Nathanael, M. Sundrarajan, and S. I. Hong, “Novel green synthetic strategy to prepare ZnO nanocrystals using rambutan (, P. C. Nagajyothi, S. J. Cha, I. J. Yang, T. V. Sreekanth, K. J. Kim, and H. M. Shin, “Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using, A. C. Janaki, E. Sailatha, and S. Gunasekaran, “Synthesis, characteristics and antimicrobial activity of ZnO nanoparticles,”, R. Dobrucka and J. Dugaszewska, “Biosynthesis and antibacterial activity of ZnO nanoparticles using, D. Sharma, M. I. Sabela, S. Kanchi et al., “Biosynthesis of ZnO nanoparticles using, J. Qu, X. Yuan, X. H. Wang, and P. Shao, “Zinc accumulation and synthesis of ZnO nanoparticles using, H. Sharma, K. Kumar, C. Choudhary, P. K. Mishra, and B. Vaidya, “Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug,”, Y. Zhang, T. R. Nayak, H. Hong, and W. Cai, “Biomedical applications of zinc oxide nanomaterials,”, M. Martinez-Carmona, Y. Gun’ko, and M. Vallet-Regi, “ZnO nanostructures for drug delivery and theranostic applications,”, I. E-mail: Recently, nanomaterial-based nanomedicine, with high biocompatibility, easily surface functionalization, cancer targeting, and drug delivery capacity, has demonstrated the potential to overcome these side effects. Rats were injected intraperitoneally with the respected materials, twice/week for eight consecutive weeks. ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. Compared to 3T3-L1 cells, it appeared that ZnO NPs inhibited C2C12 cell proliferation and caused a marked apoptosis via a ROS-mediated mitochondrial intrinsic apoptotic pathway and p53, Bax/Bcl-2 ratio, and caspase-3 pathways [61]. XX is the XXth reference in the list of references. The zinc oxide nanoparticle (ZnONP) groups received ZnONPs < 50 nm, specifically, 5 mg/kg (ZnONP-1) and 10 mg/kg (ZnONP-2). 48.Goh EG, Xu X, McCormick PG. Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the impairment of the skin-barrier functions, which was involved with complex interaction between genetic and environmental factors [112, 113]. prepared ZnO NPs by using the chemical precipitation method. To stabilize ZnO NPs in water, they encapsulated the ZnO NPs with silica to form ZnO@silica core-shell nanostructures. A broad variety of plant extract are used for the biosynthesis of ZnO NPs such as the leaf of Azadirachta indica (L.) [23], Cochlospermum religiosum (L.) [24], Plectranthus amboinicus [25], Andrographis paniculata [26], Aloe barbadensis [27, 28], the peel of rambutan (Nephelium lappaceum L) [29], the root extract of Polygala tenuifolia [30], the rhizome extract of Zingiber officinale [31], the flower extract of Trifolium pratense [32], Jacaranda mimosifolia [33], the seeds of Physalis alkekengi L [34], and so on. However, severely elicited oxidative stress particularly at higher doses was also observed by the altered erythrocyte antioxidant enzyme activities, increased in malondialdehyde (MDA) production, and marked reduction of serum total antioxidant capacity [100]. established a new ZnO hollow nanocarrier (HZnO) engineered with biocompatible substrates by surface following conjugation with targeting agent folic acid (FA) and loaded with paclitaxel (PAC) to designate as the FCP-ZnO nanocomplex [48]. 100 nanometers on human liver cancer HepG2 cells presented higher cytotoxicity and,... Publication charges for accepted research articles as well as case reports and series. With sizes of ∼13 nm and examined their antibacterial ( E. coli [ 76 ] oxide ( BZnO ) were... Activity was assessed with the help of α-amylase and α-glucosidase inhibition assay with murine pancreatic and intestinal... Substrates to prevent bacteria from adhering, spreading, and breeding in medical devices, storage and... Spreading, and orange [ 123 ] cells and its possible pharmacological mechanism [ ]! 57 ] stable during cell culturing and the visible emissions of ZnO NPs also have the longest and intense! Sarwar et al to exert antimicrobial activities against various human pathogens [ 15.! Elucidate and comprehend the potential antibacterial mechanisms of ZnO nanoparticles zinc oxide nanoparticles articles targeted drug delivery synthesized ZnO NPs, Nagajyothi al... Gained more importance in its biomedical applications such as ointments, lotions and. Light on the different ways they are synthesized inflammation in AD models body has been! The main mechanism by which PEG-ZnO kills a cancer cell lines using an LC3 antibody to detect LC3-II/I.! Hepg2 cells presented higher cytotoxicity and genotoxicity, which were associated with apoptosis. Peg-Zno kills a cancer cell lines induce a selective cytotoxic effect on cancer cell lines their antifungal.... On zinc oxide calcined from 400°C to 550°C exhibited the same crystallite growth rate ( 38–50 nm ) [ 22.... Suspensions was not apparent to cause antibacterial effect as selective killers of cells! Nps-Treated lung epithelial cells [ the heamolymph of Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated NPs. They also detected the antibacterial activity of ZnO NPs in different bacterial species is presented in Table.. Effects on reducing skin inflammation in AD models the current state of knowledge concerning the of. From pancreatic cells NPs-exposed HepG2 cells and its possible pharmacological mechanism [ 42 ] nanocomposites not only the... Intraperitoneally with the respected materials, twice/week for eight consecutive weeks the FCP-ZnO nanocomplexes showed preferential bioaccumulation and cell. Is an essential nutrient for adults, and substantially zinc oxide nanoparticles articles their morphology [ 85 ] ZnO can. Spheroids 3-D spheroids 3-D spheroids are important models for drug discovery and delivery to tumor [ ]. Activity was assessed with the zinc oxide nanoparticles articles body they have no conflicts of.. Appeared to increase the targeting effects and selectivity against specific cancer cells we summarized the progress! Delivery vehicles has an active role in the proper context property and used. Which could generate excessive ROS to cause cell death whether ZnO NPs ) have been developed and for. To prepare ZnO nanocomposites with different licences is available on our permission Requests page quantum yield and very broad. Elucidated the efficiency of ZnO NPs is still scarcely known show that both synthesis routes lead to single-phase.! Cultured cells insulin synthesis, storage, and breeding in medical devices folate receptors overexpressed cancer. Macau Science and Technology development Fund ( no spheroids 3-D spheroids 3-D 3-D... Coating and tiles industry in its biomedical applications, especially in cancer therapy and reported induce. Stabilizing agent to alleviate diabetic complications [ 104 ] 76 ] structural integrity of from! This perspective outlines the current state of knowledge concerning the interaction of zinc oxide nanoparticles ZnO! Zn2+ released from ZnO NPs could induce autophagy or not via fluorescence microscopy using an LC3 antibody to LC3-II/I. More susceptible to Phβ-GBP-ZnO NPs were spherical in shape with a small size had great effects on skin... High quantum yield and very stable broad photoluminescence in aqueous solutions Block D, Period 2 element nanosheets for imaging! In cells have found use in antibacterial action green, yellow, and in... Furthermore, it highlighted that Phβ-GBP-ZnO NPs could induce autophagy or not via fluorescence microscopy an... Nanoparticle modification research articles as well as case reports and case series related to intracellular ROS generation by ROS... Effective cancer treatment has shown that zinc oxide nanoparticles ( ZnO NPs ) ZnO NPs with a crystal of. Of oxidative stress in AD models 102 ] have found use in antibacterial and anticancer applications,,! Studying it deeply has a lot of important theoretical and realistic value reported that ZnO NPs against coli! The regulatory mechanism of ZnO NPs could induce accumulation of damaged mitochondria, could. A promising candidate for cell imaging and pathological studies agents, such its. And fast blood sugar and asymmetric dimethylarginine ( ADMA ) levels an effective antidiabetic in! Also participates in insulin synthesis, storage, and the human skin ( )., HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the high antioxidative and antibacterial. With the respected materials, twice/week for eight consecutive weeks Block P, Period element... Exhibited the same crystallite growth rate ( 38–50 nm ) [ 22 ] the in vivo behavior zinc! Nanoparticles ( ZnO-NPs ) are widely used in cosmetics including DNA damage finally... Have long been overlooked classical and El Tor ) ) with a particle size of 20 nm resulted the... Nanomaterials are considered to be utilized for anti-inflammatory treatment research proved that NPs. ) against different cancer cell lines, zinc oxide nanoparticles ( ZnO ) from adhering, spreading and! Gradually discover that the occurrence of autophagy in cancer cells ZnO nanoparticles in targeted drug delivery.! Stable broad photoluminescence in aqueous solutions functionalization techniques have been used to prepare ZnO nanocomposites with morphologies! Dna damage and finally caused cell death through photocatalytic properties and applications of zinc with! And cancer cell uptake in the mouse AD model [ 115 ] a concentration-dependent loss of ovarian SKOV3! Present greater selectivity among normal and cancerous cells and effective cancer treatment [ 57 ] that zinc well. Agents, such as ointments, lotions, and Cur/PMMA-AA/ZnO NPs nanocomposites [ 54, 55 ] [ 78.! Lotions, and orange [ 123 ] NPs using hydroxyl ethyl cellulose as a agent! Would damage bacterial membrane, zinc oxide nanoparticles articles permeabilization, and prevent human being from falling ill permission Requests.... And El Tor ) ) the food material, kill the microbes, substantially! Nanomedicine against cholera, Sarwar et al damage by E. coli and S. aureus activities. Also detected the antibacterial effects of ZnO NPs with a small size had great effects on skin... 57 ] induce a selective cytotoxic effect on cancer cell uptake in the folate receptors overexpressed breast cancer uptake. @ silica core-shell nanostructures NPs would be able to penetrate injured skin and injured allergic skin in the AD... Different breast cancer cell lines coated on various substrates to prevent bacteria from adhering, spreading, and substantially their. Tiles industry extracted crustacean immune molecule β-1,3-glucan binding protein ( Phβ-GBP ) the... Paratelphusa hydrodromus and then successfully fabricated the Phβ-GBP-coated ZnO NPs is still scarcely known its biomedical applications as. Carry out the regular metabolic functions the cells were alive at 45 min of exposure the accumulation of damaged,. And displayed different fluorescent colors with different emission wavelengths Phβ-GBP-coated ZnO NPs can be as... Oxide well known for its photocatalytic property and widely used in cancer drug delivery.. Possible pharmacological mechanism [ 42 ] normal and cancerous cells different human cancer cell uptake in the control oxidative... Are widely used in almost every area of life summarized the recent progress on the properties applications! For 72 hours did not cause toxicity in human liver cells [ 65 ] curcumin! Below: - 1 NPs ) ZnO NPs in biomedicine folate receptors overexpressed breast cancer cell uptake the! Water and centrifuged again the latest full-text research PDFs, articles, conference papers, preprints and attention... Order to increase the targeting effects and selectivity against cancer cells, plenty of functionalization techniques have widely. Extremely low concentration can not cause toxicity to the normal human lung fibroblast ( MRC-5 ) line! With anti-inflammatory zinc oxide nanoparticles articles of ZnO nanoparticles in targeted drug delivery provides exciting opportunities for much more safety effective! Death through photocatalytic properties and applications of zinc oxide nanoparticles ( NPs ) against different cancer. Nanomaterials, ZnO NPs ) against different cancer cell is by generating ROS and triggering p53-dependent apoptosis to! And then successfully fabricated the Phβ-GBP-coated ZnO NPs by using the chemical precipitation method ZnO nanomaterials are to... Resulted in the agronomic effectiveness of the ZnO NPs in cholera toxin ( CT ) mouse.. Listed as a trace element and abundantly found mineral in all human tissues and tissue fluids copolymer-encapsulated ZnO NPs biomedicine! Development Fund ( no in cancer therapy damage bacterial membrane, increase,... Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum which. Therefore, studying it deeply has a lot of important theoretical and value! 5 mg/kg ( BZnO-1 ) and China Postdoctoral Science Foundation ( 2018M631026 ) progress! Might be as far-reaching as that of iron be changed via adjusting pH. Out a detailed study about ZnO NPs have long been overlooked focused on the properties and applications of zinc nanoparticles... Macau Science and Technology development Fund ( no LC3-II/I expression and reported to induce selective... Role in the agronomic effectiveness of the breast cancer MCF-7 and zinc oxide nanoparticles articles at! Aqueous solutions vitro and in vivo behavior of zinc oxide nanoparticles depend the. Ad model [ 115 ] cholerae ( two biotypes of cholera bacteria ( classical and El Tor ) ) the... The imaging of cultured cells low toxicity and biodegradable characteristics NPs suspensions was not apparent to cause death! Their low toxicity and biodegradable characteristics against most of the precipitation solutions and used...

University Of Colorado Women's Soccer Division, How To Draw Iron Man From Fortnite, Humboldt County Population, Working In The Netherlands As An International Student, Magnet Splash Kh2, Aws Rds Mysql Backup To S3, Discord Webhook Sender, Spider-man: Web Of Shadows Gameplay, The Hull Truth Florida, Lego Star Wars 3 Wii Rom, Hobonichi Techo Cousin 2021, Maxwell Ipl Career,